Endocrine Abstracts

There are 1.21 million deaths from road traffic accidents worldwide. In Afghanistan, there have been 2005 battle injuries over 10 years. Advances in military trauma care have improved survival, resulting in more severely injured individuals entering the trauma care pathway. Improved understanding of endocrine-immune changes after severe trauma may facilitate novel interventions to improve outcomes. We prospectively recruited 102 severely injured patients at the Queen Elizabeth...

Current guidelines on cardiovascular (CV) disease prevention recommend targeted management after assessment of CV risks using many of available method even if the patient is asymptomatic. This study was performed to explore how CV high-risk is differently detected between two distinct methods: non-invasive test (NIT) and risk calculation and how the awareness of CV high-risk impacts physician and patient behavior for risk management in diabetes patient.A...

Observational studies suggest reduced vitamin D levels are associated with an increased incidence of type 2 diabetes mellitus. We examined the relationship with insulin resistance (assessed using a two-step euglycaemic hyperinsulinaemic clamp technique) in 92 overweight, non-diabetic individuals with no history of cardiovascular disease - mean age 56 years (range 40–77 years), 64% males, 36% females, BMI 30.9 kg/m2 (range 26.4–36.9 kg/m2), fasti...

Mitotane (o,p’DDD) represents the most effective treatment of adrenocortical carcinoma (ACC). However, molecular mechanisms of mitotane action remain poorly understood. Mitochondrial (mt) impact of mitotane has previously been suggested but not yet fully validated. We investigated functional consequences of mitotane exposure on mitochondrial steroidogenesis, respiratory chain activity and biogenesis, using human adrenocortical secreting H295R and non-secreting SW13 cells....

Context: The effects of cabergoline on cardiac valves have been extensively studied in Parkinson’s disease and hyperprolactinemia but not in acromegaly, a condition at risk of cardiac valve abnormalities.Objective: We examined the prevalence of heart valve disease and regurgitation in a series of patients with acromegaly treated with cabergoline, by comparison with matched patients who had never received this drug.Design and s...

Introduction: Recently low circulating levels of sex hormone binding globulin (SHBG) have been shown to be a strong predictor of the risk of developing type 2 diabetes. Genetic studies suggest that this may be a primary causal abnormality and the mechanism may relate to effects on insulin resistance.Methods: Insulin resistance was assessed using a two-step euglycaemic hyperinsulinaemic clamp (EHC) in 87 (59 male and 28 post-menopausal female) overweight ...

Missense loss-of-function mutations in TAC3 and TACR3, the genes encoding neurokinin B (NKB) and its receptor NK3R, respectively, were recently discovered in kindreds with non syndromic normosmic congenital hypogonadotropic hypogonadism (nCHH), thus identifying a fundamental role of this pathway in the human gonadotrope axis.We investigated the consequences on gonadotrope axis of TAC3 and TACR3 invalidations in adult patients ...

Glucocorticoid receptor (GR or NR3C1) is a ligand-dependent transcription factor that plays an essential role in differentiation, development, inflammatory responses and energy balance and is implicated in several human diseases. Eleven germinal GR mutations have been described so far, responsible for glucocorticoid resistance with variable clinical presentation.We report original heterozygous GR mutations in three independent patients, which have been i...

Context: Peritoneal carcinomatosis (PC) is a rare site of distant metastasis in patients with adrenocortical cancer (ACC). One preliminary study suggests an increase risk of PC after adrenalectomy through laparoscopic approach of ACC.Objective: The objective of the study was to search for risk factors of PC including surgical approach. This was a retrospective cohort study conducted in an institutional practice.Patients: Sixty-four...

The prevalence of polycystic ovary syndrome (PCOS) is generally estimated at 5–7% in women of reproductive age. But studies regarding the prevalence of PCOS have largely been confined to non-Asians. We aimed to estimate prevalence and phenotype of PCOS in Korean women. Cross sectional study was done between November 2008 and May 2009. A questionnaire based on menstrual history and clinical manifestations of hyperandrogenism was utilized to find out ‘probable cases&#1...